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Pre Transplant in Indore

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Before undergoing a transplant, a thorough evaluation is essential, encompassing:

Imaging-tests
Imaging:
  • CT scans of the head, chest, and abdomen.
  • X-rays of the upper GI tract.
  • X-ray of the small bowel.
  • Ultrasound for detailed visualization of internal organs.
  • Endoscopy for a comprehensive examination.
Blood-tests
Blood and Genetic Testing:
  • Blood tests, including gene compatibility assessments.
  • Cancer screening tests to evaluate overall health.
General-health-exam
Medical and Psychological Assessment:
  • General health exam, including physical examination.
  • Social and psychological evaluation to gauge stress, financial factors, and support systems.
Social-and-psychological-evaluation
Additional Tests
  • Stress tests, pulmonary function testing, heart catheterization, and motility studies.
Ultrasound
Colonoscopy and Ultrasound/h5>
  • Colonoscopy to inspect the entire colon.
  • Ultrasound to create internal organ images using sound waves.

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Pre-Transplant in Indore

Before undergoing intestinal transplant treatment in Indore, it's essential to consult with a doctor and understand the potential waiting period. Due to a higher demand for transplants than available organs, the waiting time in India can be considerably long. While awaiting the transplant, your doctor will initiate necessary treatments to maintain your well-being and readiness for the procedure. It's crucial to keep your doctor informed if there are any changes in your health during this waiting period.

Intestinal Transplant Process

Upon organ availability, the hospital will urgently admit you and provide information. Tests and evaluations are conducted to assess your health for surgery. Anesthesia is administered in the operating theater before the procedure. Some patients may require ventilator support based on their health conditions.

The surgery involves making an incision, evaluating the abdomen for abnormalities, and removing the intestine. The donated organ(s) are then placed in the abdomen. A stoma is created for monitoring, and a Gastrojejunostomy tube may be inserted.

After the procedure, the incision is closed.

Surgical Complications

During or shortly after intestinal transplant surgery, certain complications may arise, including:

  • Wound Infection
  • Blood Clot Formation: Artery or vein clotting in the lungs, heart, spleen, pancreas, or liver.
  • Diabetes Development
  • Bile Leakage from Bile Ducts
  • Uncontrollable Bleeding

Immunosuppressant-Related Complications

To facilitate the adjustment of the new organ in the body, immunosuppressants are prescribed. However, this comes with potential complications, exposing the recipient to various infectious diseases.

Rejection:

  • In some cases, the body may not accept the new organ, leading to potential dysfunction. The immune system may recognize the transplanted organ as foreign, increasing the risk of rejection.

Side Effects of Anti-Rejection Medications:

  • Medications prescribed for liver function and overall health can result in significant side effects, including:
    • Weight Gain
    • High Blood Pressure
    • Kidney Damage
    • Cholesterol Imbalance

Vascular Complications

Thrombosis:

  • Formation of clots in the artery or vein of the newly transplanted intestine, causing a halt in blood supply.

Bleeding:

  • High risk of internal bleeding associated with major surgeries, potentially requiring blood transfusion and additional surgical intervention.

Leak:

  • Occasional leaks may occur where the new intestine is connected to the recipient's organ, necessitating surgical intervention to rectify the issue.

Laboratory Evaluation

Prior to the transplant, a comprehensive laboratory evaluation is conducted, including:

  • Blood Group (ABO): To determine compatibility with a potential donor.
  • Complete Blood Count (CBC): To assess the degree of anemia and planning pre-transplant treatment.
  • Urine Routine and Culture: To rule out urinary tract infection and assess proteinuria levels.
  • Liver Function Tests: To detect any impairment in liver function.
  • Blood Glucose: To evaluate diabetes status and control.
  • Lipid Profile: To identify abnormalities and plan appropriate treatment.
  • Renal Function Tests: To assess preoperative electrolytes for fitness.
  • Coagulation Tests (PT/PTT/BT): To rule out bleeding and coagulation abnormalities.
  • Viral Disease Screening (HbsAg/HCV/HIV/EBV/CMV IgG): To detect and treat viral diseases, activating prophylaxis as needed after transplant.
  • Tissue Typing/HLA: To determine compatibility between the donor and recipient.
  • Lymphocyte Cross-Match: To identify antibodies against donor T and B cells, assessing compatibility and the risk of organ rejection.
  • Uroflowmetry Post-Void Residue: To assess obstruction and bladder status before transplant.
  • CT Scan/Iliofemoral Vessel Doppler: To detect kidney stones or calcifications in iliac blood vessels where donor kidney vessels will be joined.
  • Gastrointestinal Endoscopy: To be required for selected patients showing positive stool occult blood or a history of peptic ulcers.

Donor Evaluation

People interested in donating undergo thorough health assessments to ensure their well-being and compatibility. This involves examining the heart and lungs, assessing blood group compatibility, and conducting crossmatch tests to understand potential immune system risks, as mandated by the Human Organ and Tissue Transplant Act.

Health Assessment for Donors

Individuals considering kidney donation undergo meticulous health checks to verify their overall health, ensure they don't carry any illnesses transmissible to the recipient, and can safely donate a kidney. The evaluation includes a comprehensive examination of the heart and lungs, and a battery of relevant medical tests, to obtain a thorough understanding of their health.

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